Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hippocampus, long-term potentiation and memory

S Redman1

  • 1Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Clinical and Experimental Pharmacology & Physiology
|October 1, 1996
PubMed
Summary

Long-term potentiation (LTP) involves increased AMPA current and active sites at CA1 neurons. Causal links between LTP and memory formation remain uncertain, requiring advanced genetic techniques for clarification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Attenuated psychosis symptoms are related to working alliance between therapist and service user.

Early intervention in psychiatry·2024
Same author

Co-production of knowledge: the future.

BMJ (Clinical research ed.)·2021
Same author

Report from the Annual Conference of the British Society of Echocardiography, October 2018, ACC Liverpool, Liverpool.

Echo research and practice·2020
Same author

Deconstructing knowledge brokering for commissioned rapid reviews: an observational study.

Health research policy and systems·2018
Same author

Sensitivity to reinforcement in successive and delayed discriminations.

Behavioural processes·2014
Same author

Microdamage and altered vascularity at the enthesis-bone interface provides an anatomic explanation for bone involvement in the HLA-B27-associated spondylarthritides and allied disorders.

Arthritis and rheumatism·2006

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Learning and Memory

Background:

  • Long-term potentiation (LTP) at CA1 pyramidal neurons involves increased quantal AMPA current and active sites.
  • The role of presynaptic modifications and retrograde messengers in LTP induction remains unclear.

Purpose of the Study:

  • To investigate the mechanisms underlying LTP induction.
  • To clarify the causal relationship between LTP and memory formation.

Main Methods:

  • Analysis of synaptic currents and active site dynamics.
  • Review of pharmacological and genetic studies on NMDA and mGLU receptors.
  • Discussion of advanced genetic techniques for future research.

Main Results:

Related Experiment Videos

  • LTP induction is associated with enhanced AMPA receptor function and increased synaptic sites.
  • Current evidence does not definitively establish a causal link between LTP and memory consolidation.
  • Existing genetic and pharmacological studies show correlations but not causation.

Conclusions:

  • While LTP mechanisms are partially understood, its direct causal role in memory formation requires further investigation.
  • Novel approaches like tissue- and time-specific gene expression manipulation are needed to elucidate LTP's function in memory.
  • Future research should focus on establishing definitive causal links using precise genetic tools.