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Low molecular weight IgM in healthy adults: influence of HLA
1Department of Clinical Immunology, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, Australia.
Circulating LMW IgM was detected in a group of 100 healthy adults, but in very low or trace concentrations. A significant correlation was observed between total IgM and LMW IgM (r = 0.81, p < 0.01), which suggests that the presence of LMW IgM may be due to the "overspill" of LMW IgM during IgM synthesis and secretion. Significantly higher levels of LMW IgM and total IgM were found in females as compared with males. Furthermore, a weak association between A1, B8, DR3 and elevated IgM was also found. However the precise significance of this association is unclear.
Circulating LMW IgM was detected in a group of 100 healthy adults, but in very low or trace concentrations. A significant correlation was observed between total IgM and LMW IgM (r = 0.81, p < 0.01), which suggests that the presence of LMW IgM may be due to the "overspill" of LMW IgM during IgM synthesis and secretion. Significantly higher levels of LMW IgM and total IgM were found in females as compared with males. Furthermore, a weak association between A1, B8, DR3 and elevated IgM was also found. However the precise significance of this association is unclear.