On the role of recurrent inhibitory feedback in motor control

This article reviews presumed roles of recurrent inhibition in motor control, that have been proposed over the past five decades. The discussion is structured in an order of increasing complexity. It starts out with the simplest and earliest circuit, that is recurrent self-inhibition of skeleto-motoneurons, and related functions. It soon becomes clear that in order to understand recurrent inhibition, we must look beyond the simple self-inhibitory CNS circuit. First, recurrent inhibition must be seen in the context of other neural circuits. Second, some quantitative features appear to be correlated with features of the neuromusculo-skeletal periphery. Third, the aspect of lateral inhibition between different members of a motoneuron pool as well as between different motoneuron pools points to the essential multiple input-multiple output structure of recurrent inhibition that again can be understood only by correlating it with features of the neuromusculo-skeletal periphery. Another extension results from the discovery that recurrent inhibition affects not only skeleto-motoneurons, but also gamma-motoneurons, Ia inhibitory interneurons mediating reciprocal inhibition between antagonist motoneurons, other Renshaw cells and cells of origin of the ventral spinocerebellar tract (VSCT). Then the view broadens again, investigating the potential role that recurrent inhibition plays in two far-ranging theories of motor control, the inverse-dynamics approach and the equilibrium-point hypothesis. Finally, the present author tries to formulate, in broad strokes, a personal functional interpretation of recurrent inhibition. All the functional considerations, right or wrong, should yield ideas for new experiments, and this then is the last objective of this review.