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Transient acantholytic dermatosis (Grover's disease): a global perspective
Journal of the American Academy of Dermatology
|November 1, 1996
Summary
Grover's disease, or transient acantholytic dermatosis, is a skin condition that can persist. Its cause is unknown but may relate to heat, sweat, or dry skin.
Area of Science:
- Dermatology
- Pathology
Background:
- Grover's disease (transient acantholytic dermatosis) was first described 26 years ago.
- The understanding of Grover's disease has evolved to encompass persistent forms.
- Its etiology remains unclear, but potential triggers include heat, sweating, and xerosis.
Purpose of the Study:
- To review the current understanding of Grover's disease.
- To discuss the classification and potential causes of acantholytic disorders.
Main Methods:
- Literature review of studies on transient and persistent acantholytic dermatoses.
- Analysis of the proposed etiological factors and current classification.
Main Results:
- Grover's disease is now understood to include persistent variants.
- The condition is characterized as a nonfamilial, non-immune-mediated, acantholytic disorder.
- Excessive heat, sweating, or xerosis are considered potential contributing factors.
Conclusions:
- Grover's disease encompasses both transient and persistent forms.
- It is classified as an idiopathic acantholytic condition.
- Further research into the specific triggers is warranted.