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Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease
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6-Hydroxycatecholine, a choline-mimicking analogue of the selective neurotoxin, 6-hydroxydopamine

R Shen1, L M Tillekeratne, J R Kirchhoff

  • 1Department of Medicinal and Biological Chemistry College of Pharmacy, Toledo, Ohio 43606, USA.

Biochemical and Biophysical Research Communications
|November 1, 1996
PubMed

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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