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Related Experiment Videos

Possible paroxetine-induced bruxism

F Romanelli1, D A Adler, K M Bungay

  • 1University of Kentucky Medical Center, Lexington 40536, USA.

The Annals of Pharmacotherapy
|November 1, 1996
PubMed
Summary

This case study highlights a patient experiencing bruxism potentially caused by paroxetine, a selective serotonin reuptake inhibitor (SSRI). The bruxism symptoms significantly improved after treatment with buspirone.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Dentistry

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression.
  • Bruxism, characterized by teeth grinding and clenching, has been linked to certain SSRIs like fluoxetine and sertraline.
  • The potential for paroxetine to induce bruxism requires clinical attention.

Observation:

  • A 20-year-old woman developed dental damage consistent with bruxism after initiating paroxetine for depression.
  • The patient's bruxism symptoms, including tooth pain and jaw tenderness, emerged after paroxetine dosage adjustments.
  • Dental examinations prior to paroxetine therapy had not revealed any tooth damage.

Findings:

  • The case suggests a potential link between paroxetine use and the development of bruxism.
  • Treatment with buspirone resulted in a significant reduction in the patient's bruxism symptoms.
  • This response to buspirone aligns with previous reports on managing SSRI-induced bruxism.

Implications:

  • Clinicians should consider paroxetine as a potential cause of new-onset bruxism in patients.
  • Buspirone may be an effective therapeutic option for managing paroxetine-induced bruxism.
  • Further research into the mechanisms of SSRI-induced bruxism is warranted.

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