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Evaluation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4
Y Hashimoto1, H Kagechika, E Kawachi
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Biological & Pharmaceutical Bulletin
|October 1, 1996
Abstract:
Retinoids, including all-trans-retinoic acid (ATRA), its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. Binding activity of typical retinoids to nuclear retinoic acid receptors (RARs) was also investigated. A good linear correlation between the ED50 values of differentiation-inducing activity towards HL-60 cells and those towards NB4 cells was found. Binding activities of retinoids to RAR alpha and RAR beta also correlated well to the differentiation-inducing activities.