Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peritoneal dialysis kinetic modeling: validation in a multicenter clinical study

E F Vonesh1, J Burkart, S D McMurray

  • 1Applied Statistics Center, Baxter Healthcare Corporation, Round Lake, Illinois 60073, USA.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|September 1, 1996
PubMed
Summary

This study validates a computer model for peritoneal dialysis (PD), showing excellent agreement for urea and creatinine clearances. The model aids in managing dialysis prescriptions and checking patient compliance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The reluctant innovator: orangutans and the phylogeny of creativity.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2016
Same author

Comparison of particulate number concentrations in three Central European capital cities.

The Science of the total environment·2012
Same author

Long-term study of cloud condensation nuclei (CCN) activation of the atmospheric aerosol in Vienna.

Atmospheric environment (Oxford, England : 1994)·2011
Same author

The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial.

Kidney international·2011
Same author

The danger of using inappropriate point-of-care glucose meters in patients on icodextrin dialysis.

Diabetic medicine : a journal of the British Diabetic Association·2011
Same author

Characterizing the performance of two optical particle counters (Grimm OPC1.108 and OPC1.109) under urban aerosol conditions.

Journal of aerosol science·2010

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Clinical Informatics

Background:

  • Peritoneal dialysis (PD) requires precise management of solute and fluid removal.
  • Kinetic modeling offers a potential tool for optimizing PD prescriptions.
  • Clinical validation is essential to confirm the reliability of such models.

Purpose of the Study:

  • To clinically validate a computer-based kinetic model for PD.
  • To assess agreement between measured and modeled urea/creatinine clearances and ultrafiltration (UF).

Main Methods:

  • An open, multicenter observational study involving 111 continuous ambulatory peritoneal dialysis (CAPD) patients.
  • Patients underwent a 4-hour peritoneal equilibration test (PET) with variable fill volumes.
  • Measured and modeled clearances (urea, creatinine) and UF were compared using correlation and limits of agreement analysis.

Related Experiment Videos

Main Results:

  • Excellent agreement (concordance correlation 0.94 for urea, 0.92 for creatinine) between measured and modeled clearances.
  • Good agreement for ultrafiltration (concordance correlation 0.50) with precision within +/- 0.919 L/day.
  • 94% of modeled urea clearances and 87% of creatinine clearances fell within clinical agreement limits.

Conclusions:

  • A validated kinetic model, combined with PET data, is a powerful tool for CAPD prescription management.
  • Kinetic modeling can predict outcomes for alternative prescriptions.
  • The model can assist in identifying potential patient noncompliance.