[Impaired glucose tolerance--current concept and its classification]

Area of Science:

• Endocrinology
• Metabolic Disorders
• Clinical Diagnostics

Context:

• The oral glucose tolerance test (OGTT) is a key diagnostic tool for glucose metabolism disorders.
• Historical diagnostic criteria for glucose intolerance have evolved significantly.
• Standardization of OGTT interpretation remains a challenge in clinical practice.

Purpose:

• To critically evaluate the historical development and current challenges of the oral glucose tolerance test (OGTT).
• To review the evolution of diagnostic criteria for glucose intolerance and diabetes mellitus.
• To discuss the application and limitations of OGTT in diabetes diagnosis.

Summary:

• This review examines fundamental problems associated with the oral glucose tolerance test (OGTT).
• It provides a historical perspective on changing diagnostic criteria for glucose intolerance and diabetes mellitus diagnosis.
• Key historical proposals and recommendations from NIH, WHO, and Japan Diabetes Society are discussed.

Impact:

• Provides a comprehensive overview of OGTT's historical context and diagnostic utility.
• Identifies persistent challenges and areas for future research in glucose tolerance testing.
• Informs clinicians and researchers about the nuances of OGTT interpretation and its role in diabetes management.