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[Mild glucose intolerance in the elderly]

K Oba1, H Nakano, K Okazaki

  • 1Division of Geriatric Medicine, Nippon Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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As people age, glucose tolerance declines primarily due to insulin resistance, not changes in insulin production. Lifestyle factors like diet and exercise worsen this age-related glucose intolerance.

Area of Science:

  • Gerontology
  • Metabolic Science
  • Endocrinology

Context:

  • Age-related decline in glucose tolerance is a significant health concern.
  • Understanding the mechanisms behind impaired glucose metabolism in aging is crucial.

Purpose:

  • To elucidate the primary mechanisms responsible for age-associated glucose intolerance.
  • To identify contributing factors to insulin resistance in the elderly.

Summary:

  • Glucose tolerance decreases with age, mainly due to increased insulin resistance rather than diminished insulin secretion.
  • Factors such as diet composition, reduced physical activity, and loss of lean body mass contribute to this insulin resistance.

Impact:

  • Mild glucose intolerance in older adults elevates the risk of developing type 2 diabetes.

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  • Age-related glucose intolerance is also a risk factor for cardiovascular diseases, including atherosclerosis.