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[Changes in the microcirculation of the myocardium in pulmonary embolism]
Abstract:
The author induced experimental lung embolia by venous administration of liquid fat or licopodium spores in 26 rabbits. Materials, obtained from myocardium of the experimental animals, were examined histologicaly and histochemicaly. The method of Lie et al. (1971) was used for establishing early ischemic changes in myofibers. The author recommended licopodium embolia as a good model for examining changes in myocardium after lung embolia. She indicated development of shock phenomena in animals with lung embolia, presenting signs of coronary insufficiency, including formation of sites of ischemic myofibers. With these changes the author explained the serious difficulties at the clinic in diagnosing and differentiating lung embolia from myocardial infarction even after electrocardiographic control.
Insights
This study used rabbits to model lung embolism, revealing ischemic changes in heart muscle. These findings help explain diagnostic challenges differentiating lung embolism from myocardial infarction.
Area of Science:
- Cardiovascular Pathology
- Pulmonary Medicine
- Experimental Pathology
Background:
- Lung embolism diagnosis can be challenging, often confused with myocardial infarction.
- Understanding myocardial changes secondary to lung embolism is crucial for clinical differentiation.
Purpose of the Study:
- To establish a reliable animal model for studying myocardial alterations following lung embolism.
- To investigate early ischemic changes in the myocardium induced by experimental lung embolism.
Main Methods:
- Induction of experimental lung embolism in 26 rabbits using liquid fat or licopodium spores.
- Histological and histochemical examination of myocardial tissues.
- Application of Lie et al. (1971) method for detecting early ischemic changes in myofibers.
Main Results:
- Licopodium spore embolism served as an effective model for examining myocardial changes.
- Animals with lung embolism exhibited shock phenomena and signs of coronary insufficiency.
- Formation of ischemic myofiber sites was observed in the myocardium.
Conclusions:
- Experimental lung embolism in rabbits effectively models myocardial ischemia.
- Observed myocardial changes can account for clinical difficulties in distinguishing lung embolism from myocardial infarction.
- The study highlights the importance of considering myocardial effects in lung embolism cases.