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HPV typing of vulvovaginal condylomata in children

C A Wright1, L Taylor, K Cooper

  • 1Department of Anatomical Pathology, South African Institute for Medical Research, Johannesburg.

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|October 1, 1995
PubMed

Insights

Human papillomavirus (HPV) DNA was detected in childhood vulvovaginal warts, with HPV 11 being the most common subtype. This finding suggests potential sexual abuse and warrants further investigation.

Area of Science:

  • Medical Microbiology
  • Pediatric Gynecology
  • Forensic Pathology

Background:

  • Vulvovaginal warts in prepubescent children can be indicative of human papillomavirus (HPV) infection.
  • Determining HPV subtypes is crucial for understanding transmission routes and potential implications.

Purpose of the Study:

  • To identify the specific human papillomavirus (HPV) subtypes present in vulvovaginal warts of prepubescent children.
  • To investigate the association between HPV detection and potential indicators of sexual abuse.

Main Methods:

  • A histopathology case series design was employed.
  • Samples from children under 12 with vulvovaginal warts were analyzed using non-isotopic in situ hybridisation (NISH) and polymerase chain reaction (PCR).
  • Specific genital HPV types (6, 11, 16, 18, 31, 33, 35) were targeted.

Main Results:

  • Human papillomavirus (HPV) DNA was detected in all 9 (100%) of the analyzed biopsies.
  • HPV type 11 was identified in 8 out of 9 (89%) of the vulvovaginal warts using NISH.
  • PCR confirmed the presence of HPV DNA in all cases.

Conclusions:

  • The detection of genital HPV subtypes in childhood condylomata acuminata strongly suggests sexual abuse.
  • Findings should guide further investigation by a multidisciplinary team.
  • Early identification of HPV in children necessitates careful evaluation and management.
Abstract

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