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A new procedure for the purification of streptococcal pyrogenic exotoxin A from Streptococcus pyogenes supernatant
E M Mascini1, M A Hazenberg, L A Verhage
1Eijkman-Winkler Institute for Microbiology, Utrecht University Hospital, The Netherlands.
Clinical and Diagnostic Laboratory Immunology
|November 1, 1996
Abstract:
An important role in the pathogenesis of invasive group A streptococcal disease has been ascribed to the production of streptococcal pyrogenic exotoxin A. We present a new technique for the purification of streptococcal pyrogenic exotoxin A from Streptococcus pyogenes NY-5 supernate, which is highly efficient with respect to yield (35%), purity (> or = 99%), and time.