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New drugs in gynecologic oncology
E A Eisenhauer1, J B Vermorken
1NCIC Clinical Trials Group, Queen's University, Kingston, Ontario, Canada.
Current Opinion in Oncology
|September 1, 1996
Abstract:
New agents with activity in recurrent epithelial ovarian cancer include the taxoids (paclitaxel and docetaxel), camptothecins (topotecan and irinotecan), gemcitabine, and oxaliplatin. In front-line therapy, the Gynecologic Oncology Group has shown that paclitaxel prolongs survival. In recurrent squamous carcinoma of the cervix, irinotecan has an objective response rate of 15%-24%. Both paclitaxel and docetaxel also show modest activity. Of these new agents, only paclitaxel has been evaluated in carcinoma of the endometrium, reporting a response rate of 35%.