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Prognostic factors affecting outcome in lower gingival carcinoma
S M Overholt1, S A Eicher, P Wolf
1Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston, USA.
The Laryngoscope
|November 1, 1996
Summary
Tumor size and positive surgical margins significantly impact local control for lower gingiva squamous cell carcinoma. Advanced T stage, positive margins, and cervical metastases adversely affect survival in these rare mandibular-invading cancers.
Area of Science:
- Oral Oncology
- Surgical Pathology
Background:
- Squamous cell carcinoma (SCC) of the lower gingiva is a rare malignancy.
- This cancer frequently exhibits invasion into the mandible.
Purpose of the Study:
- To identify prognostic factors for local disease control.
- To determine factors influencing overall survival in lower gingiva SCC.
Main Methods:
- Retrospective review of 155 previously untreated patients.
- Analysis of clinical and pathological variables affecting outcomes.
Main Results:
- Primary lesions >3 cm and positive surgical margins correlated with decreased local control.
- Advanced T stage, positive margins, mandibular invasion, and cervical metastases were associated with poorer survival.
- Tumor size was a more critical predictor of local control than mandibular invasion.
Conclusions:
- Tumor size is a key factor in local disease control for lower gingiva SCC.
- Mandibular invasion, while common, is less predictive of local control than tumor size.
- Larger tumors necessitate more extensive surgical resection due to higher recurrence risk and poorer survival.