Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The microcirculation in venous hypertension

P D Smith1

  • 1Department of Surgery, UCL Medical School, Middlesex Hospital, London, UK. p.coleridgesmith@ucl.ac.uk

Cardiovascular Research
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Racism on Oral Health in the United States.

Community dental health·2021
Same author

Ongoing design concerns of portable oxygen cylinders.

Anaesthesia and intensive care·2018
Same author

Helicobacter pylori infection is associated with an altered gastric microbiota in children.

Mucosal immunology·2017
Same author

Chyle leak following right axillary lymph node dissection: A case report and review of current literature.

International journal of surgery case reports·2016
Same author

Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells.

Mucosal immunology·2014
Same author

Bilateral spontaneous, simultaneous lower extremity hematomas in a patient on dalteparin.

International journal of surgery case reports·2013
Same journal

YAP plays a critical role in myocardial recovery from myocarditis by suppressing IFN-γ signaling pathway.

Cardiovascular research·2026
Same journal

Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder.

Cardiovascular research·2026
Same journal

Personalizing Atrial Fibrillation Therapy: Moving from Genetic Association to Mechanistic Translation.

Cardiovascular research·2026
Same journal

Placental Growth Factor Promotes Endothelial Activation and Inflammatory Remodelling in Pulmonary Hypertension.

Cardiovascular research·2026
Same journal

Endothelial-to-mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models and therapies.

Cardiovascular research·2026
Same journal

The gut-heart axis in cardio-oncology.

Cardiovascular research·2026
See all related articles

Chronic venous insufficiency can cause skin ulceration, likely due to neutrophil activation and subsequent endothelial injury, rather than simple diffusion issues. Further research into these mechanisms could improve patient treatment.

Area of Science:

  • Dermatology
  • Vascular Biology
  • Immunology

Background:

  • Chronic venous insufficiency (CVI) is a condition characterized by impaired blood flow in the veins.
  • Skin ulceration is a common and debilitating complication of CVI, significantly impacting patient quality of life.

Purpose of the Study:

  • To review the factors contributing to skin ulceration in patients with CVI.
  • To elucidate the underlying mechanisms of venous ulcer pathogenesis.

Main Methods:

  • A comprehensive literature search was conducted using Index Medicus (1966-1995).
  • Articles focusing on the mechanisms of venous ulceration and treatment efficacy were included.

Main Results:

  • Venous ulceration is unlikely due to impaired diffusion of oxygen or nutrients.

Related Experiment Videos

  • Neutrophil activation and adhesion to the microcirculation, leading to endothelial injury, are strongly implicated.
  • Chronic inflammation and lipodermatosclerosis result from repeated microvascular injury.

    • Conclusions:

    • Leukocyte involvement is evident in the pathogenesis of venous ulceration.
    • The precise mechanisms require further investigation.
    • A better understanding of these basic causes may lead to improved therapeutic strategies for CVI patients.