Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Coronary Syndrome V: Nursing Management

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial.

Leukemia·2023

Same author

Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients.

The British journal of dermatology·2021

Same author

Correction to: Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality.

Leukemia·2021

Same author

Myelodysplastic syndromes: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<sup>†☆</sup>.

Annals of oncology : official journal of the European Society for Medical Oncology·2020

Same author

[Behçet's-like syndrome and other dysimmunitary manifestations related to myelodysplastic syndromes with trisomy 8].

La Revue de medecine interne·2020

Same author

Effects of azacitidine in 93 patients with <i>IDH1/2</i> mutated acute myeloid leukemia/myelodysplastic syndromes: a French retrospective multicenter study.

Leukemia & lymphoma·2020

Same journal

The place of instruments in the scientific work of Marcel Bessis (1917-1994): the electron microscope and the ektacytometer.

Hematology and cell therapy·2001

Same journal

In memory of Marcel Bessis.

Hematology and cell therapy·2001

Same journal

Emerging therapies and future directions in CLL--monoclonal antibodies, vaccines and gene therapy.

Hematology and cell therapy·2000

Same journal

Emerging therapies and future directions in chronic lymphocytic leukaemia--chemotherapy.

Hematology and cell therapy·2000

Same journal

Chronic lymphocytic leukemia . Clinical oral poster session.

Hematology and cell therapy·2000

Same journal

Current therapy for CLL.

Hematology and cell therapy·2000

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

Myelodysplastic syndromes

¹Service des Maladies du Sang, CHU, Lille, France.

Hematology and Cell Therapy

|October 1, 1996

Summary

This summary is machine-generated.

This review covers myelodysplastic syndromes, detailing their epidemiology, biology, diagnosis, prognosis, and treatment options for better patient outcomes.

More Related Videos

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

Related Experiment Videos

Last Updated: Feb 6, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

Area of Science:

Hematology
Oncology
Clinical Medicine

Background:

Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
MDS are characterized by ineffective hematopoiesis and a high risk of transformation to acute myeloid leukemia.

Purpose of the Study:

To provide a comprehensive overview of myelodysplastic syndromes.
To synthesize current knowledge on the epidemiological, biological, diagnostic, prognostic, and therapeutic aspects of MDS.

Main Methods:

Systematic literature review.
Analysis of epidemiological data.
Review of biological mechanisms.
Evaluation of diagnostic criteria and prognostic scoring systems.
Assessment of current and emerging therapeutic strategies.

Main Results:

Epidemiological data highlight varying incidence rates across different populations.
Biological insights reveal key genetic mutations and cellular pathways involved in MDS pathogenesis.
Diagnostic approaches rely on morphological, cytogenetic, and molecular analyses.
Prognostic models effectively stratify patients based on risk.
Therapeutic options range from supportive care to intensive treatments, including stem cell transplantation and novel agents.

Conclusions:

Myelodysplastic syndromes require a multidisciplinary approach for optimal management.
Advances in understanding MDS biology are driving the development of targeted therapies.
Accurate diagnosis and risk stratification are crucial for guiding treatment decisions.