Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine

¹Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London, UK. marranzc@hgmp.mrc.ac.uk

|October 18, 1996

Abstract:

Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT2A receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.

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Abstract:

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