Repeating hemorrhage with a long duration after radiotherapy for glioma: radiological and histological observations

A case of radiation necrosis which was observed 6 years after radiotherapy for a glioma in the right parietal lobe is reported. This patient developed hemiparesis, and radiological examinations showed similar findings consisted with recurrent glioma. Histological examination disclosed the lesion to be radiation necrosis. Repeated episodes of hemorrhage and cystic formation in the right hemisphere appeared during 8 to 10 years after radiotherapy, and removal of the mass lesion conducted four times. Histological examinations of each specimen showed the increasing proliferation of neo-vessels accompanied by hemorrhage and cystic formation.