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Melanocytes in malignant ameloblastoma

¹Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.

Pathology International

|October 1, 1996

Summary

This study reports a rare case of malignant ameloblastoma in a Japanese female, featuring melanocytosis within the tumor. It highlights the first instance of melanocytosis in an odontogenic epithelial tumor.

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Area of Science:

Oral Pathology
Oncology
Dermatopathology

Background:

Ameloblastoma is a common odontogenic tumor, typically benign but with malignant potential.
Malignant transformation of ameloblastoma is rare and poorly understood.
Melanocytosis, the presence of melanin pigment, is not a typical feature of ameloblastoma.

Observation:

A 63-year-old Japanese female presented with an unusual ameloblastoma in the maxilla.
Histopathological examination revealed features of a less-differentiated malignant ameloblastoma.
Dendritic cells containing melanin pigment were observed within tumor nests invading bone and soft tissue.

Findings:

The tumor exhibited characteristic malignant ameloblastoma features alongside melanocytosis.
Melanin granules were present in the cytoplasm of some tumor cells.
No melanocytes or melanin pigment were found in the tumor stroma.

Implications:

This case represents the first documented instance of melanocytosis in an odontogenic epithelial tumor.
The findings suggest a potential link between ameloblastoma and melanocytic differentiation.
Further research is needed to elucidate the histogenesis of melanocytes in this context.

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