Noradrenaline reversal in canine subcutaneous adipose tissue

Although adrenaline reversal is a well known phenomenon, fewer investigations have demonstrated reversal of the vascular response to noradrenaline (NA). The present studies compared subcutaneous adipose tissue vascular responses to intra-arterial NA with those of sympathetic nerve stimulation. Both NA and electrical stimulation produced vasoconstriction in adipose tissue which was reversed to beta-adrenergically mediated vasodilation following local alpha-adrenergic block.