Is there a correlation between osteoclastic activity and the action of calcitonin on macrophagic activity?

The formation of granulomas from a foreign body was studied by means of the subcutaneous implantation of cotton fragments in rats treated with salmon calcitonin or with just the diluent. The formation of granulomas was evaluated in optical microscopy, transmission and scanning electron microscopy (TEM and SEM, respectively). The cellular populations of the granuloma were immunophenotyped and flow analyzed in cytofluorometry (FACS = fluorescence-activated cell sorter). In the group treated with calcitonin, a lesser inflammatory effect of the cotton fragments was found compared to the group treated with only the diluent. These results indicate that, in addition to inhibiting bone resorption, salmon calcitonin has several important anti-inflammatory effects.