Related Experiment Videos
Drug induced acute generalized exanthematous pustulosis
1Department of Dermatology, Oita Medical University, Japan.
The Journal of Dermatology
|September 1, 1996
Summary
A drug allergy caused a severe skin reaction with pustules and fever in a patient. Isepamicin sulfate and/or cadralazine were identified as potential culprits, highlighting rare adverse drug reactions.
Area of Science:
- Dermatology
- Allergology
- Ophthalmology
Background:
- Diabetic triopathy and vitreous hemorrhage can necessitate medical interventions.
- Adverse drug reactions can manifest with diverse dermatological symptoms.
- Acute Generalized Exanthematous Pustulosis (AGEP) is a rare, severe cutaneous adverse drug reaction.
Observation:
- A patient developed widespread erythematous macules, pustules, and fever post-vitreous hemorrhage treatment.
- Symptoms resolved upon drug discontinuation, suggesting a drug-induced etiology.
- Patch testing indicated isepamicin sulfate as a likely allergen.
Findings:
- A positive patch test strongly implicated isepamicin sulfate in the patient's reaction.
- Cadralazine was also a potential culprit, indicated by a positive drug lymphocyte stimulation test (DLST).
- Ofloxacin yielded a false-positive DLST, later disproven by a challenge test.
Implications:
- This case highlights the potential for isepamicin sulfate and/or cadralazine to induce acute generalized exanthematous pustulosis (AGEP).
- It underscores the importance of comprehensive drug allergy testing in diagnosing rare cutaneous adverse drug reactions.
- Physicians should consider these drugs when evaluating patients presenting with similar pustular eruptions.