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Nonconvulsive status epilepticus after intravenous contrast medium administration
T G Lukovits1, C E Fadul, J M Pipas
1Section of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Epilepsia
|November 1, 1996
Summary
This study reports a rare case of contrast medium-induced status epilepticus in a glioblastoma patient. Prompt treatment resolved the prolonged seizure and aphasia, highlighting a potential adverse effect of CT contrast agents.
Area of Science:
- Neurology
- Radiology
- Oncology
Background:
- Glioblastoma multiforme presents unique challenges in patient management.
- Computed tomography (CT) scans with intravenous contrast are standard diagnostic tools.
Observation:
- A 52-year-old glioblastoma patient experienced prolonged partial seizures and aphasia post-CT scan.
- Electroencephalogram (EEG) confirmed status epilepticus (SE) in the left temporal and parietal regions.
Findings:
- Intravenous contrast medium administration was temporally associated with the onset of SE.
- Treatment with lorazepam and phenytoin led to rapid clinical improvement.
- Follow-up EEG at 2 months showed no epileptiform discharges.
Implications:
- This case suggests a potential link between iodinated contrast media and SE in susceptible patients.
- Further investigation is warranted to understand the mechanism of contrast-induced SE.
- Clinicians should be aware of this rare adverse event in neuro-oncology patients undergoing CT scans.