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The role of SSRIs in panic disorder
D V Sheehan1, K Harnett-Sheehan
1University of South Florida, Institute for Research in Psychiatry, Tampa 33613-4706, USA.
The Journal of Clinical Psychiatry
|January 1, 1996
Summary
Serotonin uptake inhibitors are effective and well-tolerated treatments for panic disorder, surpassing placebo and older alternatives. These findings establish them as a preferred first-line therapy for managing panic disorder.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Medicine
Background:
- Panic disorder is a significant mental health condition.
- Traditional treatments for panic disorder have limitations.
- Clinical experience often precedes research findings.
Purpose of the Study:
- To review the efficacy of serotonin uptake inhibitors in panic disorder.
- To compare these agents with placebo and older treatments.
- To assess their tolerability in clinical practice.
Main Methods:
- Systematic review of published literature.
- Inclusion of studies presented at national and international meetings.
- Analysis of efficacy and tolerability data.
Main Results:
- Serotonin uptake inhibitors demonstrate superiority over placebo.
- These agents are better tolerated than many older panic disorder treatments.
- Emerging data support their clinical effectiveness.
Conclusions:
- Serotonin uptake inhibitors are effective first-choice treatments for panic disorder.
- Their favorable efficacy and tolerability profile support widespread clinical adoption.
- The findings align research data with growing clinical experience.