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Related Experiment Videos

Reduction of gallstone formation by ascorbic acid in hamsters

E Ginter, L Mikus

    Experientia
    |June 15, 1977
    PubMed
    Summary

    Adding ascorbic acid to a cholesterol-rich diet reduced gallstone formation in hamsters. This vitamin also lowered cholesterol levels and sped up its conversion into bile acids.

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    Area of Science:

    • Biochemistry
    • Nutrition
    • Metabolic studies

    Background:

    • Gallstones are primarily formed from cholesterol.
    • Dietary factors significantly influence cholesterol metabolism and gallstone development.
    • Ascorbic acid (vitamin C) plays a role in various metabolic processes.

    Purpose of the Study:

    • To investigate the effect of ascorbic acid supplementation on cholesterol metabolism and gallstone formation.
    • To determine how ascorbic acid influences cholesterol levels and its transformation into bile acids in a hamster model.

    Main Methods:

    • Golden hamsters were fed a lithogenic (gallstone-inducing) diet.
    • The hamsters' body cholesterol pool was labeled with 26-14C-cholesterol.
    • 0.5% ascorbic acid was added to the diet of the experimental group.

    Main Results:

    • Ascorbic acid supplementation significantly reduced gallstone formation.
    • Cholesterol concentration and half-life in blood plasma and liver were decreased.
    • The transformation of cholesterol into bile acids was accelerated.

    Conclusions:

    • Ascorbic acid exhibits a protective effect against cholesterol gallstone formation.
    • Ascorbic acid favorably modulates cholesterol metabolism, reducing its accumulation and enhancing its clearance.
    • Dietary ascorbic acid may be a viable strategy to manage cholesterol homeostasis and prevent gallstones.

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