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Transglutaminase induction by various cell death and apoptosis pathways
1Department of Biochemistry, University Medical School of Debrecen, Hungary.
Abstract:
Clarification of the molecular details of forms of natural cell death, including apoptosis, has become one of the most challenging issues of contemporary biomedical sciences. One of the effector elements of various cell death pathways is the covalent cross-linking of cellular proteins by transglutaminases. This review will discuss the accumulating data related to the induction and regulation of these enzymes, particularly of tissue type transglutaminase, in the molecular program of cell death. A wide range of signalling pathways can lead to the parallel induction of apoptosis and transglutaminase, providing a handle for better understanding the exact molecular interactions responsible for the mechanism of regulated cell death.
Insights
Tissue type transglutaminase plays a key role in programmed cell death pathways. This review explores how transglutaminase induction is regulated, aiding understanding of cell death mechanisms.
Area of Science:
- Biomedical Sciences
- Molecular Biology
- Cell Death Research
Background:
- Apoptosis and other forms of regulated cell death are critical biological processes.
- Transglutaminases are enzymes involved in protein cross-linking, implicated in various cellular functions.
- Understanding the molecular mechanisms of cell death is a major challenge in contemporary biomedical research.
Purpose of the Study:
- To review current data on the induction and regulation of transglutaminases in cell death.
- To elucidate the role of tissue type transglutaminase in the molecular program of cell death.
- To explore the interplay between signaling pathways, apoptosis, and transglutaminase activity.
Main Methods:
- Literature review of accumulating data on transglutaminase.
- Analysis of signaling pathways leading to cell death.
- Examination of molecular interactions in regulated cell death.
Main Results:
- Transglutaminases are effector elements in various cell death pathways.
- Signaling pathways can induce both apoptosis and transglutaminase activity concurrently.
- Tissue type transglutaminase is a key enzyme in the molecular program of cell death.
Conclusions:
- The induction and regulation of transglutaminases are integral to cell death.
- Understanding transglutaminase's role provides insights into the molecular mechanisms of regulated cell death.
- Further research into these molecular interactions can advance the field of cell death biology.