Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diverse molecular provocation of programmed cell death

I E Wertz1, M R Hanley

  • 1Department of Biological Chemistry, School of Medicine, University of California at Davis 95616, USA.

Trends in Biochemical Sciences
|October 1, 1996
PubMed
Summary

Genetic and pharmacological tools help study programmed cell death. New research explores how cells sense and respond to these tools, influencing cell survival outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DUBs, the regulation of cell identity and disease.

The Biochemical journal·2015
Same author

The Gabo fountain, St Thomas' Hospital.

Journal of the Royal Society of Medicine·2010
Same author

Regulation of death receptor signaling by the ubiquitin system.

Cell death and differentiation·2009
Same author

Multiple embolic events in a patient with heparin induced thrombocytopaenic thrombotic syndrome and mural thrombus.

Anaesthesia and intensive care·2005
Same author

Messenger RNA localization and further characterisation of the putative tachykinin receptor NK4 (NK3B).

Receptors & channels·2001
Same author

Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells.

The Journal of biological chemistry·2001

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Programmed cell death (apoptosis) is crucial for development and disease.
  • Genetic and pharmacological tools are vital for studying apoptosis.
  • Understanding cellular responses to these tools is key.

Purpose of the Study:

  • To review recent advances in understanding molecular sensing of apoptosis-inducing/blocking tools.
  • To explore the downstream consequences of detecting cellular perturbations.
  • To connect these mechanisms to cell survival decisions.

Main Methods:

  • Literature review of experimental studies.
  • Analysis of molecular pathways involved in cell death sensing.
  • Discussion of genetic and pharmacological manipulation techniques.

Main Results:

  • Identification of novel molecular sensors for cellular stress.
  • Elucidation of signaling cascades triggered by experimental perturbations.
  • Correlation between sensing pathways and cell fate determination.

Conclusions:

  • Cellular sensing mechanisms play a critical role in apoptosis.
  • Precise understanding of these pathways can refine therapeutic strategies.
  • Further research into molecular sensing will advance cell death manipulation.

Related Experiment Videos