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Telomerase and cancer: revisiting the telomere hypothesis
1Cold Spring Harbor Laboratory, NY 11724, USA.
Trends in Biochemical Sciences
|October 1, 1996
Abstract:
Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.