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Venous tone evaluation by elastic modulus and therapeutic implications

G Geroulakos¹, A Nicolaides

¹Irvine Laboratory for Cardiologic Investigation and Research, Academic Surgical Unit, St. Mary's Hospital, London, England.

International Angiology : a Journal of the International Union of Angiology

|September 1, 1995

Summary

Venous tone, crucial for venous insufficiency, can now be measured non-invasively. A new air plethysmography method accurately assesses venous elasticity, aiding drug development for venous disorders.

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Area of Science:

Cardiovascular Physiology
Vascular Biology

Background:

Venous tone significantly impacts cardiac output and venous return.
Understanding venous tone is critical for managing venous insufficiency and related conditions.
Current methods for assessing venous tone have limitations, particularly for drug efficacy studies.

Purpose of the Study:

To develop and validate a non-invasive method for assessing venous tone.
To quantify the elastic modulus (K) of veins using air plethysmography.
To evaluate the potential of this technique for studying phlebotonic agents.

Main Methods:

Comparison of invasive strain gauge plethysmography with a novel non-invasive air plethysmography technique.
Measurement of pressure-volume relationships to calculate the elastic modulus (K).

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Assessment of reproducibility in healthy volunteers.

Main Results:

Invasive methods revealed distinct elastic modulus values for normal limbs, varicose veins, and deep venous incompetence.
Individuals at high risk for varicose veins exhibited abnormal elastic modulus values.
The non-invasive air plethysmography method demonstrated good reproducibility.

Conclusions:

A non-invasive air plethysmography technique effectively measures venous elastic modulus (K).
This method offers a reproducible and potentially less invasive alternative to existing techniques.
The technique is suitable for evaluating phlebotonic agents in patients at risk of venous insufficiency.