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Juvenile generalized pustular psoriasis
1Department of Dermatology, S.T.D., and Leprosy, Dr. Sampurnanand Medical College, Jodhpur, India.
Insights
A severe pustular skin condition in a young child improved significantly with methotrexate treatment. This medication, administered weekly, effectively reduced widespread skin inflammation and toxicity.
Area of Science:
- Pediatric Dermatology
- Immunosuppressive Therapy
Background:
- A 4-year-old boy presented with a generalized, confluent, pustular eruption on an erythematous base.
- The condition had persisted for three weeks, accompanied by fever and toxicity, with a history of a similar episode in infancy.
Abstract:
A 4-year-old boy had a generalized, confluent, pustular eruption on an erythematous base of three weeks' duration. He was febrile and toxic. He had had a similar problem at age 5 months that lasted for about four weeks. The child was initially treated conservatively, but later developed erythroderma and became increasingly toxic. This necessitated administration of oral methotrexate 2.5 mg/day at weekly intervals. After two pulses there was marked improvement in his psoriasis.