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Blockade by ginseng total saponin of methamphetamine-induced hyperactivity and conditioned place preference in mice
1Department of Pharmacology, Chungbuk National University, Cheongju, Korea.
General Pharmacology
|March 1, 1996
Abstract:
Ginseng total saponin (GTS) inhibited methamphetamine-induced hyperactivity and conditioned place preference (CPP). Dopamine (DA) receptor supersensitivity was developed in methamphetamine-induced CPP mice and it was inhibited by GTS. GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic activity of GTS. These results suggest that GTS inhibition of the methamphetamine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by methamphetamine.