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Recombination load associated with selection for increased recombination

B Charlesworth1, N H Barton

  • 1Department of Ecology and Evolution, University of Chicago, IL 60637-1573, USA. bcworth@pondside.uchicago.edu

Genetical Research
|February 1, 1996
PubMed
Summary

Genetic recombination can lower progeny fitness, creating a

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Area of Science:

  • Evolutionary genetics
  • Population genetics

Background:

  • Genetic recombination's impact on offspring fitness is debated.
  • Recombination load may indicate direct fitness effects or epistatic selection maintaining linkage disequilibria.

Purpose of the Study:

  • To investigate the expected recombination load even when selection favors increased recombination.
  • To explore the evolutionary consequences of recombination under different selection models.

Main Methods:

  • Theoretical modeling of selection on recombination modifiers.
  • Analysis of genetic variance and response to selection.

Main Results:

  • A recombination load is expected even with selection favoring recombination.
  • Increased recombination leads to higher additive genetic variance in fitness, enabling faster adaptation.
  • This phenomenon applies to mutation-selection balance, quantitative trait selection, and transposable element dynamics.

Conclusions:

  • The immediate fitness cost of recombination may be offset by long-term adaptive benefits.
  • Further empirical studies are required to balance the immediate load against increased additive variance.

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