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Progress in the development of Lactococcus lactis as a recombinant mucosal vaccine delivery system
P M Norton1, R W Le Page, J M Wells
1Department of Pathology, University of Cambridge, UK.
Folia Microbiologica
|January 1, 1995
Abstract:
The non-pathogenic, non-colonising Gram-positive organism Lactobacillus lactis is beeing developed as an antigen delivery system for mucosal vaccination. A high level expression system has been developed which allows loading of the bacterium with high levels of a heterologous antigen (TTFC) prior to inoculation. Mucosal inoculation of one such recombinant strain results in a protective serum antibody response and production of TTFC-specific IgA at mucosal sites.