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Typhoid hepatitis

A B Durrani1

  • 1Department of Medicine, Bolan Medical College, Quetta.

JPMA. the Journal of the Pakistan Medical Association
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Typhoid hepatitis, a rare complication of typhoid fever, presents with jaundice and liver enlargement. This study highlights its prevalence and the need for accurate diagnosis in febrile patients.

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Area of Science:

  • Infectious Diseases
  • Hepatology
  • Clinical Medicine

Background:

  • Typhoid fever is common in Pakistan.
  • Typhoid hepatitis is a rare but challenging presentation of typhoid fever.
  • Clinical suspicion arises from persistent fever, hepatomegaly, jaundice, and specific liver function test patterns.

Purpose of the Study:

  • To determine the incidence of typhoid hepatitis in Pakistan.
  • To emphasize the importance of considering typhoid hepatitis in differential diagnoses.
  • To advocate for accurate and simple diagnostic methods for typhoid fever.

Main Methods:

  • A retrospective study of 476 typhoid fever cases from January 1989 to December 1994.
  • Inclusion of patients admitted to JPMC Karachi (204 cases) and Civil Hospital, Quetta (272 cases).

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  • Analysis of clinical presentation, liver function tests, and serological markers for viral hepatitis.

    • Main Results:

    • Typhoid hepatitis was observed in 11% of typhoid fever cases.
    • 4% of cases were initially misdiagnosed as viral hepatitis.
    • 7% of cases developed jaundice during their illness.

    Conclusions:

    • Typhoid hepatitis is a significant presentation of typhoid fever in endemic areas.
    • Accurate diagnostic tools are crucial for timely identification.
    • Typhoid hepatitis should be a key differential diagnosis in patients with fever, jaundice, and hepatomegaly.