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Human thioredoxin reductase gene localization to chromosomal position 12q23-q24.1 and mRNA distribution in human
J R Gasdaska1, P Y Gasdaska, A Gallegos
1Arizona Cancer Center, University of Arizona, Tucson 85724-5024, USA.
Genomics
|October 15, 1996
Abstract:
Thioredoxin reductase is a member of the pyridine nucleotide-disulfide oxidoreductase family of enzymes. By delivering reducing equivalents to thioredoxin, thioredoxin reductase exerts control over a number of redox-sensitive factors in the cell, including ribonucleotide reductase and several transcription factors. We have localized the human thioredoxin gene to chromosomal position 12q23-q24.1 by in situ hybridization. We have also determined the relative tissue distribution of thioredoxin reductase mRNA as well as thioredoxin mRNA by probing a Northern blot of several human normal tissues.