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Isolation of two cytotoxic diterpenes from the fern Pteris multifida
H J Woerdenbag1, L R Lutke, R Bos
1Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies (GIDS), University of Groningen, The Netherlands.
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|September 1, 1996
Abstract:
From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, entkaurane-2 beta, 16 alpha-diol and ent-kaur-16-ene-2 beta, 15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.