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Circulating immune complexes and renal function in canine leishmaniasis

R Lopez1, R Lucena, M Novales

  • 1Department of Veterinary Clinical Pathology, Faculty of Veterinary of Córdoba, Spain.

Zentralblatt Fur Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B
|October 1, 1996
PubMed
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Dogs infected with leishmania show significantly higher levels of circulating immune complexes (CIC). High CIC concentrations in infected dogs may indicate renal function impairment, suggesting a link between CIC and kidney damage in canine leishmaniasis.

Area of Science:

  • Veterinary Immunology
  • Canine Infectious Diseases
  • Parasitology

Background:

  • Canine leishmaniasis is a significant parasitic disease.
  • Circulating immune complexes (CIC) are implicated in various immune-mediated diseases.
  • Assessing CIC levels can provide insights into disease pathogenesis.

Purpose of the Study:

  • To quantify IgG CIC levels in dogs with leishmania infection.
  • To compare CIC concentrations between infected and healthy dogs.
  • To investigate the relationship between CIC levels and renal function in infected dogs.

Main Methods:

  • Utilized a third component of complement (C3) capture enzyme-linked immunosorbent assay (ELISA).
  • Measured IgG CIC concentrations in 91 leishmania-infected dogs and 24 healthy controls.

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  • Analyzed CIC levels in relation to hypercreatininemia (elevated creatinine).

    • Main Results:

    • Leishmania-infected dogs exhibited significantly higher mean CIC concentrations (228.7%) compared to healthy controls (74.5%).
    • Elevated CIC levels were detected in 57.1% of infected dogs.
    • Infected dogs with hypercreatininemia showed significantly higher CIC levels than those with normal creatinine.

    Conclusions:

    • Elevated serum IgG CIC concentrations are a hallmark of canine leishmaniasis.
    • Hypercreatininemia in infected dogs is strongly associated with high CIC levels, suggesting renal impairment.
    • CIC measurement may serve as a valuable indicator for assessing kidney function in canine leishmaniasis.