Properties of an oxygen-sensitive mutant mev-3 of the nematode Caenorhabditis elegans
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1Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Mutation Research
|October 28, 1996
Abstract:
A spontaneous mutant of mev-3 of the nematode Caenorhabditis elegans was isolated on the basis of its resistance to methyl viologen, which generates superoxide radicals. Contrary to expectation, the mutant proved hypersensitive to oxygen. Oxygen retarded development and reduced fecundity in a concentration-dependent fashion in mev-3 but not in wild-type. In addition, the mean life span of mev-3 (but not wild-type) was progressively shortened when animals were incubated under 70% oxygen.