Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axonal processes and neural plasticity. II: Adult somatosensory maps

T Elliott1, C I Howarth, N R Shadbolt

  • 1Department of Psychology, University of Nottingham, UK.

Cerebral Cortex (New York, N.Y. : 1991)
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival and temporal change in the viability of <i>Ascaridia galli</i> eggs exposed to refrigeration or freezing temperatures in the presence of a cryoprotectant.

Journal of helminthology·2025
Same author

Translation of Prognostic and Pharmacodynamic Biomarkers from Trial to Non-trial Patients with Metastatic Castration-resistant Prostate Cancer Treated with Docetaxel.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Viability and development of <i>Ascaridia galli</i> eggs recovered in artificial media followed by storage under different conditions.

Journal of helminthology·2020
Same author

Glycerin suppositories used prophylactically in premature infants (supp): A pilot randomized controlled trial.

Journal of neonatal-perinatal medicine·2020
Same author

Utility of Prognostic Markers in Second-line Treatment of Metastatic Urothelial Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2017
Same author

A national survey of current practices of preparation and management of radical prostate radiotherapy patients during treatment.

Radiography (London, England : 1995)·2017

Axonal sprouting and retraction can explain long-term changes in adult sensory maps, demonstrating a unified framework for neural plasticity across development and maturity. This mechanism applies to different sensory modalities and systems.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Previous work introduced a framework for axonal process sprouting and retraction to explain ocular dominance column formation.
  • Adult sensory map plasticity, particularly in the somatosensory cortex, involves complex rearrangements following altered peripheral input.
  • Existing models, such as synapse-specific Hebbian models with normalization, may struggle to account for both developmental and adult plasticity.

Purpose of the Study:

  • To apply the existing axonal process sprouting and retraction framework to model adult somatosensory map plasticity.
  • To investigate the role of axonal sprouting and retraction in mediating long-term changes induced by anomalous peripheral activity in mature systems.
  • To demonstrate the framework's versatility across different sensory modalities and developmental stages.

Related Experiment Videos

Main Methods:

  • Modeling the rearrangement of the primary somatosensory cortex (S-I) in adult rodents after vibrissae denervation.
  • Modeling the rearrangement of area 3b in adult monkeys subsequent to digit hyperstimulation.
  • Focusing on long-term structural changes rather than rapid synaptic modifications like unmasking or potentiation.

Main Results:

  • The axonal process sprouting and retraction framework successfully models somatosensory map rearrangements in adult animals.
  • The study demonstrates that axonal sprouting and retraction is a viable mechanism for long-term plasticity driven by peripheral changes.
  • The framework's ability to account for plasticity in both developing and mature systems, across different sensory modalities, is highlighted.

Conclusions:

  • Axonal process sprouting and retraction provides a unified mechanism for neural plasticity in both developing and adult sensory systems.
  • This framework offers a potential explanation for long-term map reorganization following altered sensory input, contrasting with limitations of Hebbian models.
  • The study underscores the framework's adaptability and broad applicability in understanding neural map dynamics.