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Clinical trials in the elderly. Should we do more?

H J Cameron1, B O Williams

  • 1Gartnavel General Hospital, West Glasgow Hospitals University, NHS Trust, Scotland.

Drugs & Aging
|November 1, 1996
PubMed

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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