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Mean transit time of solid test meals in gastric emptying
Digestion
|January 1, 1977
Summary
This study compared two methods for measuring gastric emptying. Mean transit time (MTT) proved more reliable than half-time of emptying (T1/2) for assessing gastric emptying in healthy volunteers.
Area of Science:
- Nuclear medicine
- Gastroenterology
- Physiology
Background:
- Gastric emptying is a crucial physiological process.
- Accurate measurement of gastric emptying is essential for diagnosing gastrointestinal disorders.
Purpose of the Study:
- To compare the reliability of Mean Transit Time (MTT) and half-time of emptying (T1/2) for assessing gastric emptying.
- To determine the most suitable parameter for defining normal gastric emptying and differentiating pathological patterns.
Main Methods:
- Gastric emptying was studied in 9 healthy volunteers using a gamma-camera and on-line computer.
- A test meal labeled with 99Tcm-sulphur colloid was used.
- Mean transit time (MTT) was calculated using gamma-variate fitting.
- Half-time of emptying (T1/2) was calculated using exponential fitting.
Main Results:
- Mean transit time (MTT) exhibited a smaller coefficient of variance compared to the half-time of emptying (T1/2).
- This indicates greater consistency and reproducibility of MTT measurements.
Conclusions:
- Mean transit time (MTT) is a more suitable parameter than T1/2 for establishing normal values of gastric emptying.
- MTT may offer better discrimination between normal and pathological gastric emptying patterns.