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Skeletal responsiveness to thyroid hormone is not altered at menopause
B L Langdahl1, A G Loft, N Møller
1Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Denmark.
Bone
|November 1, 1996
Summary
Menopause does not alter thyroid hormone levels or bone sensitivity to thyroid hormone. Thyroid hormone (T3) stimulation increases bone turnover and resorption markers in both premenopausal and postmenopausal women.
Area of Science:
- Endocrinology
- Bone Metabolism
- Reproductive Health
Background:
- Hyperthyroidism and menopause increase bone turnover and resorption.
- Investigating the role of thyroid hormone in menopause-related bone changes is crucial.
Purpose of the Study:
- To compare thyroid status and bone sensitivity to thyroid hormone in premenopausal and early postmenopausal women.
- To assess the impact of triiodothyronine (T3) administration on bone remodeling markers.
Main Methods:
- Administered triiodothyronine (T3) to premenopausal and early postmenopausal women.
- Monitored serum bone alkaline phosphatase (BAP), osteocalcin (BGP), and ICTP.
- Measured urinary hydroxyproline (OHP), pyridinoline (PYR), and deoxypyridinoline (DPR).
Main Results:
- Early postmenopausal women showed higher baseline bone turnover markers (sBAP, sBGP, uOHP).
- T3 stimulation significantly increased bone resorption markers (sICTP, uOHP, UPYR) in both groups.
- Bone formation markers (sBGP, sBAP) increased later, indicating initiation of new remodeling.
Conclusions:
- Menopause is not associated with altered thyroid hormone levels or skeletal responsiveness to thyroid hormone.
- Thyroid hormone stimulates both bone formation and resorption, initiating new remodeling cycles.