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Enterobacter sepsis in the newborn--a growing problem in Karachi
1Department of Paediatrics, Aga Khan University Medical Centre, Karachi, Pakistan.
The Journal of Hospital Infection
|November 1, 1996
Summary
Enterobacter sepsis is a growing concern in neonatal intensive care units. This study highlights its significant incidence and increasing antibiotic resistance in newborns, necessitating updated treatment strategies.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Enterobacter sepsis is a recognized hospital-acquired infection in children.
- Neonatal sepsis poses a significant threat to infant health worldwide.
- Surveillance of causative pathogens and their resistance patterns is crucial for effective management.
Purpose of the Study:
- To determine the incidence and characteristics of Enterobacter sepsis in neonates.
- To assess the clinical presentation and outcomes of Enterobacter sepsis.
- To evaluate antibiotic resistance trends of Enterobacter species in neonatal sepsis.
Main Methods:
- A five-year prospective surveillance study was conducted.
- Data collected included incidence, clinical features, predisposing factors, and mortality.
- Antibiotic susceptibility testing was performed on isolated Enterobacter strains.
Main Results:
- Enterobacter sepsis accounted for 10% of neonatal sepsis cases (28/292).
- The incidence was 0.7 per thousand births among inborn infants.
- Forty-seven percent of infections presented within 72 hours of birth, with a 21% mortality rate.
- Increasing resistance to common antibiotics was observed over the study period.
Conclusions:
- Enterobacter sepsis is an emerging and significant pathogen in neonatal sepsis cases in Karachi.
- The findings underscore the need for vigilant monitoring and updated antibiotic stewardship protocols.
- Early identification and appropriate treatment are critical to reduce mortality associated with Enterobacter sepsis.