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Related Concept Videos

  • Biomedical And Clinical Sciences
  • Paediatrics
  • Infant And Child Health
  • Acinar Cell Responsiveness To Urecholine In The Rat Pancreas During Fetal And Early Postnatal Growth
  • Biomedical And Clinical Sciences
  • Paediatrics
  • Infant And Child Health
  • Acinar Cell Responsiveness To Urecholine In The Rat Pancreas During Fetal And Early Postnatal Growth

    • Related Experiment Videos

    Acinar cell responsiveness to urecholine in the rat pancreas during fetal and early postnatal growth

    L Larose, J Morisset

      Gastroenterology
      |September 1, 1977

      View abstract on PubMed

      Summary
      This summary is machine-generated.

      Rat pancreatic acinar cells gain responsiveness to cholinergic drugs after birth. Sensitivity increases significantly from day 3, peaking between days 15-21, indicating developmental acquisition of drug response.

      Related Experiment Videos

      Area of Science:

      • Gastroenterology
      • Developmental Biology
      • Pharmacology

      Background:

      • Pancreatic acinar cells are crucial for digestion, secreting enzymes like amylase, lipase, and chymotrypsin.
      • Cholinergic stimulation plays a role in regulating pancreatic exocrine secretion.
      • Understanding the developmental timeline of this response is key to pediatric gastroenterology.

      Purpose of the Study:

      • To determine the developmental stage at which rat pancreatic acinar cells acquire cholinergic responsiveness.
      • To characterize the ontogeny of enzyme release in response to cholinergic agonists during fetal and postnatal life.

      Main Methods:

      • In vitro measurement of amylase, lipase, and chymotrypsin release from rat pancreas.
      • Stimulation with urecholine (a cholinergic drug) at various postnatal ages.
      • Comparison of responses in fetal, newborn, and juvenile rats to adult controls.

      Main Results:

      • Fetal and newborn rat pancreas showed no response to urecholine.
      • A detectable response emerged by day 3 of postnatal life.
      • Pancreatic sensitivity to urecholine increased progressively from day 3, with peak responsiveness observed between days 15 and 21.

      Conclusions:

      • Rat exocrine pancreas acquires responsiveness to cholinergic stimulation around the 3rd day of postnatal life.
      • The sensitivity to cholinergic drugs increases significantly during the first three weeks after birth.
      • These findings highlight a critical window for the development of pancreatic secretory function.