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Related Experiment Videos

Posterior lens rupture in rats

K Tanaka1, S Inagaki, H Matsumoto

  • 1Development Research Laboratories, Banyu Pharmaceutical Company Ltd., Saitama, Japan.

Toxicologic Pathology
|September 1, 1996
PubMed
Summary

Posterior lens capsule rupture was observed in Sprague-Dawley rats, appearing as opaque plaques obscuring fundus view. This spontaneous ocular lesion involves extruded lens fibers and minimal inflammation, requiring consideration in safety studies.

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Area of Science:

  • Ophthalmology
  • Toxicology
  • Veterinary Pathology

Background:

  • Spontaneous ocular lesions can impact safety assessment studies.
  • Understanding incidental findings in animal models is crucial for accurate toxicological evaluations.
  • The posterior lens capsule is a critical structure for maintaining ocular integrity.

Purpose of the Study:

  • To describe a spontaneous posterior lens capsule rupture observed in Sprague-Dawley rats.
  • To characterize the pathological features of this ocular lesion.
  • To highlight the importance of recognizing such findings in safety assessment studies.

Main Methods:

  • Ophthalmoscopy for initial detection of fundus abnormalities.
  • Slit-lamp biomicroscopy and dissecting microscopy for detailed examination of opaque plaques.

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  • Light microscopy for histological evaluation of the posterior lens capsule and surrounding tissues.

    • Main Results:

    • Opaque plaques on the posterior lens capsule were identified as the cause of obscured fundus view.
    • Histological examination confirmed posterior lens capsule rupture with extrusion of lens fibers into the vitreous.
    • Mononuclear and multinucleated giant cells were present at the rupture site, with limited additional inflammatory response.

    Conclusions:

    • Posterior lens capsule rupture is a spontaneous ocular lesion observed in Sprague-Dawley rats.
    • This lesion presents as opaque plaques and involves extrusion of lens material.
    • The presence of giant cells suggests a localized reaction, but overall inflammation is minimal. Consideration of this lesion is important in safety assessment studies.