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Primary amoebic meningoencephalitis after swimming in the Rio Grande
T S DeNapoli1, J Y Rutman, J R Robinson
1Santa Rosa Children's Hospital, San Antonio, TX 78207-3198, USA.
Abstract:
We report a case of fatal primary amoebic meningoencephalitis (PAM) with Naegleria fowleri in a 13-year-old male, and review the clinical course and diagnostic autopsy findings. The boy developed the infection after swimming with relatives in the Rio Grande and in a holding tank containing water pumped from the river. The clinical and neuropathologic features of PAM are presented. The microscopic features of motile unicellular organisms with pathognomonic broad, lobate pseudopodia are diagnostic and, if recognized before death, allow for timely treatment. A public health investigation into this case implicated river water from the Rio Grande polluted with sewage as the infection source. Exposure to polluted river water from some areas of the Rio Grande may represent a risk factor for infection with Naegleria fowerli, because the high levels of coliform bacteria found in sewage and the warm, sluggish water of the river are favorable growth conditions for the amoebae. Because the Rio Grande is an international border, this case illustrates the importance of international cooperation in pollution control in the prevention of a potentially fatal infectious disease.
Insights
A fatal case of primary amoebic meningoencephalitis (PAM) caused by Naegleria fowleri occurred in a child after swimming in the Rio Grande. Sewage-polluted river water is implicated as the source, highlighting risks of recreational water exposure.
Area of Science:
- Medical Microbiology
- Neurology
- Public Health
Background:
- Primary amoebic meningoencephalitis (PAM) is a rare and often fatal infection of the central nervous system.
- Naegleria fowleri is a free-living amoeba found in warm freshwater environments.
Observation:
- A 13-year-old male contracted PAM after swimming in the Rio Grande and a river-fed holding tank.
- Clinical presentation and diagnostic autopsy revealed characteristic neuropathologic features of PAM.
Findings:
- Microscopic identification of Naegleria fowleri with broad, lobate pseudopodia confirmed the diagnosis.
- Public health investigation identified sewage-polluted Rio Grande water as the likely source of infection.
- Warm, sluggish water with high coliform counts creates favorable conditions for Naegleria fowleri proliferation.
Implications:
- Exposure to polluted recreational waters, such as the Rio Grande, poses a risk for Naegleria fowleri infection.
- Timely diagnosis based on microscopic identification is crucial for potential treatment.
- International cooperation in pollution control is essential for preventing infectious diseases along shared borders.
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