Related Experiment Videos
Altered p53 expression in Epstein Barr virus positive T cell lymphomas
1Department of Pathology and Preventive medicine, Kyung Hee University School of Medicine, Seoul, Korea.
Journal of Korean Medical Science
|December 1, 1995
Summary
Epstein-Barr virus (EBV) is linked to T cell lymphomas. This study found altered p53 protein expression in head and neck lymphomas, particularly in advanced stages and EBV-positive T cell types.
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Epstein-Barr virus (EBV) association with T cell lymphomas is suggested.
- The role of oncogenes and tumor suppressor genes in these lymphomas is unclear.
Purpose of the Study:
- To investigate p53 protein expression frequency.
- To determine the relationship between p53 expression and EBV infection in Korean head and neck (H&N) lymphomas.
Main Methods:
- Immunohistochemistry using mAb D07 for p53 protein detection.
- Epstein-Barr encoded RNA (EBER) in situ hybridization for EBV detection.
- Analysis of 33 H&N lymphoma cases (23 B cell, 10 T cell).
Main Results:
- 16 out of 33 lymphomas showed positive p53 staining.
- P53 expression was more frequent in higher grade and advanced stage lymphomas.
- EBER positivity was higher in T cell lymphomas (70%) than B cell lymphomas (8.7%).
- EBER positive lymphomas showed a trend towards higher p53 positivity (78% vs 38%).
Conclusions:
- Altered p53 protein expression occurs in H&N lymphomas.
- p53 appears to play a role in the progression of EBV-positive T cell lymphomas.
- p53 alterations are significant in late-stage lymphoma development.