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Related Experiment Videos

[Sympathomimetics and theophylline: combined use?]

R Alvarez Sintes1, R Alvarez Sintes, M R Alvarez Castro

  • 1Medicina Interna y Cuidados Intensivos, Hospital Clínico-Quirúrgico Docente, Calixto García, La Habana, Cuba.

Anales De Medicina Interna (Madrid, Spain : 1984)
|September 1, 1995
PubMed
Summary

Theophylline and salbutamol, alone or combined, improved lung function in asthma patients compared to placebo. While generally safe, higher-dose combinations showed more minor side effects.

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Area of Science:

  • Pulmonology
  • Clinical Pharmacology

Background:

  • Bronchial asthma management often involves bronchodilators.
  • Theophylline and salbutamol are commonly used agents with different mechanisms.
  • Optimizing treatment requires understanding comparative efficacy and safety profiles.

Purpose of the Study:

  • To compare the bronchodilator effects of theophylline, salbutamol, and their combinations.
  • To evaluate the toxicity and adverse reactions of these treatment regimens.
  • To determine optimal dosing for asthma management.

Main Methods:

  • A randomized crossover trial involving 30 bronchial asthma patients.
  • Comparison of five treatment groups: theophylline, salbutamol, high-dose combination, low-dose combination, and placebo.

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  • Assessment of bronchodilator effect via FEV1 and monitoring of adverse events.

    • Main Results:

    • All active treatments (theophylline, salbutamol, and combinations) significantly improved FEV1 compared to placebo.
    • No major adverse reactions or cardiotoxicity were observed, with good tolerability overall.
    • The high-dose combination regimen exhibited a higher incidence of minor adverse reactions compared to monotherapy or the low-dose combination.

    Conclusions:

    • Theophylline and salbutamol, individually and in combination, are effective bronchodilators for asthma.
    • Treatment regimens were generally well-tolerated, with no serious safety concerns.
    • Dose optimization is important, as higher combination doses may increase minor adverse effects.