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Insight into the distribution of molecular weights and higher-order structure of hyaluronans and some beta-(1 -->
L Soltés1, D Mislovicová, B Sébille
1Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Biomedical Chromatography : BMC
|March 1, 1996
Abstract:
The effects of high energy ultrasound and slightly raised temperature combined with the denaturing action of dimethylsulphoxide on the molecular weight and higher-order structure of hyaluronans and some beta-(1 --> 3)-glucans were studied by means of size exclusion chromatography (SEC) technique. Some experimental conditions connected with the (bio-)polymer sample preparation prior to its SEC analysis are overviewed in the light of informational relevance of studies where the action of a physical and/or chemical agent changes the hydrodynamic size of the m omolecule.